Chemistry has been at the forefront of modern Western medicines with the vast majority of effort focused on treating disease. However, treating disease is not the same as preserving wellness. Chemistry has been at the forefront of increased food production. However, increased food supply and production of caloric content is not the same as the realization of access to nutritional health. Chemistry has been at the forefront of imaging, diagnostics, and sensors but measuring and monitoring a problem is not the same things as solving it or preventing it.  Chemistry can play a role in significant and timely efforts to rigorously understand and deliver nutraceuticals, probiotics, and other beneficial supplements.  There is also a need to elucidate opportunities to proactively enhance positive mechanistic pathways towards proactive health.