The structures that are used to house people and their activities should be designed, constructed, and maintained to provide resilient protection while being conducive to health and wellness of the occupants and the surrounding ecosystems.  From the molecular basis of the materials throughout their life cycle to the systems to provide the requisite water, climate control, and lighting, chemistry has a significant role to play in efficiently providing safe indoor environments for humans and their activities while considering the surrounding landscape.  Further, buildings can be designed to be modular providing for future adaptions, deconstruction and reuse to avoid end of life material waste.