Reactivity is an essential part of chemical transformations and is also closely associated with the hazardous nature of many substances.  One strategy that can be employed to avoid exposures of workers or nearby communities to toxic/reactive reagents, is to generate and consume them in the processes without any significant accumulation of these substances. Through ‘in-situ’ generation, the substance needs only to be generated in minuscule quantities for the short amounts of time as it is needed before it is consumed that reaction.