In order for a discovery or innovation to have an impact on the world, it virtually always needs to be enabled by an innovation ecosystem that incorporates the essential enabling elements.  These include support for basic research and development and that R&D needs to be commercialized through thoughtful and risk-taking investment.  These roles can be filled by various actors ranging from public sector government agencies to private sector investors.  Appropriate and just intellectual property considerations need to be supported by governance and returns on investment need to be realized through adequate financial systems.  With key roles and responsibilities assured, the innovation ecosystem can be used to bring about the transformative innovations in the chemical enterprise that are needed to advance sustainability.